SKINNER LAB
p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade
Molkentine D, Molkentine J, Bridges K, Valdecanas D, Dhawan A, Bahri R, Hefner A, Kumar M, Yang L, Abdelhakiem M, Pifer P, Sandulache V, Sheth A, Beadle BM, Thames H, Mason K, Pickering CR, Meyn R, Skinner HD. Cancer Research. 2022 Mar 1;82(5):916-928. doi: 10.1158/0008-5472.CAN-21-2101. PMID: 34965932
April 2020
Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function
Kumar M, Molkentine D, Molkentine J, Bridges K, Xie T, Yang L, Hefner A, Gao M, Bahri R, Dhawan A, Frederick MJ, Seth S, Abdelhakiem M, Beadle BM, Johnson F, Wang J, Shen L, Heffernan T, Sheth A, Ferris RL, Myers JN, Pickering CR, Skinner HD. Nat Commun. 2021 Nov 3;12(1):6340. doi: 10.1038/s41467-021-26570-8. PMID: 34732714; PMCID: PMC8566594.
Addition of Metformin to Concurrent Chemoradiation in Patients With Locally Advanced Non–Small Cell Lung Cancer
The NRG-LU001 Phase 2 Randomized Clinical Trial
Skinner H, Hu C, Tsakiridis T, Santana-Davila R, Lu B, Erasmus JJ, Doemer AJ, Videtic GMM, Coster J, Yang AX, Lee RY, Werner-Wasik M, Schaner PE, McCormack SE, Esparaz BT, McGarry RC, Bazan J, Struve T, Paulus R, Bradley JD. JAMA Oncol. 2021 Sep 1;7(9):1324-1332. doi: 10.1001/jamaoncol.2021.2318. PMID: 34323922; PMCID: PMC8323052.
April 2020
HIGH EXPRESSION OF OXIDATIVE PHOSPHORYLATION GENES PREDICTS IMPROVED SURVIVAL IN SQUAMOUS CELL CARCINOMAS OF THE HEAD AND NECK AND LUNG.
Frederick M, Skinner HD, Kazi SA, Sikora AG, Sandulache VC. Sci Rep. 2020 Apr 14;10(1):6380. doi: 10.1038/s41598-020-63448-z. PMID: 32286489; PMCID: PMC7156383.
April 2020
METABOLIC RESPONSES TO METFORMIN IN INOPERABLE EARLY-STAGE NON-SMALL CELL LUNG CANCER TREATED WITH STEREOTACTIC RADIOTHERAPY: RESULTS OF A RANDOMIZED PHASE II CLINICAL TRIAL.
Chun SG, Liao Z, Jeter MD, Chang JY, Lin SH, Komaki RU, Guerrero TM, Mayo RC, Korah BM, Koshy SM, Heymach JV, Koong AC, Skinner HD. Am J Clin Oncol. 2020 Apr;43(4):231-235. doi: 10.1097/COC.0000000000000632. PMID: 31990759.
Feburary 2020
TARGETING DNA DAMAGE RESPONSE IN HEAD AND NECK CANCERS THROUGH ABROGATION OF CELL CYCLE CHECKPOINTS.
Molkentine JM, Molkentine DP, Bridges KA, Xie T, Yang L, Sheth A, Heffernan TP, Clump DA, Faust AZ, Ferris RL, Myers JN, Frederick MJ, Mason KA, Meyn RE, Pickering CR, Skinner HD. Int J Radiat Biol. 2020 Feb 25:1-8. doi: 10.1080/09553002.2020.1730014. Epub ahead of print. PMID: 32073931.
February 2019
AN IRAK1-PIN1 SIGNALLING AXIS DRIVES INTRINSIC TUMOUR RESISTANCE TO RADIATION THERAPY.
Liu PH, Shah RB, Li Y, Arora A, Ung PM, Raman R, Gorbatenko A, Kozono S, Zhou XZ, Brechin V, Barbaro JM, Thompson R, White RM, Aguirre-Ghiso JA, Heymach JV, Lu KP, Silva JM, Panageas KS, Schlessinger A, Maki RG, Skinner HD, de Stanchina E, Sidi S. Nat Cell Biol. 2019 Feb;21(2):203-213. doi: 10.1038/s41556-018-0260-7. Epub 2019 Jan 21. PMID: 30664786; PMCID: PMC6428421.
January 2019
VARIATIONS IN HPV FUNCTION ARE ASSOCIATED WITH SURVIVAL IN SQUAMOUS CELL CARCINOMA.
Gleber-Netto FO, Rao X, Guo T, Xi Y, Gao M, Shen L, Erikson K, Kalu NN, Ren S, Xu G, Fisch KM, Akagi K, Seiwert T, Gillison M, Frederick MJ, Johnson FM, Wang J, Myers JN, Califano J, Skinner HD, Pickering CR. JCI Insight. 2019 Jan 10;4(1):e124762. doi: 10.1172/jci.insight.124762. Epub ahead of print. PMID: 30626753; PMCID: PMC6485353.
June 2017
INTEGRATIVE ANALYSIS IDENTIFIES A NOVEL AXL-PI3 KINASE-PD-L1 SIGNALING AXIS ASSOCIATED WITH RADIATION RESISTANCE IN HEAD AND NECK CANCER.
Skinner HD, Giri U, Yang LP, Kumar M, Liu Y, Story MD, Pickering CR, Byers LA, Williams MD, Wang J, Shen L, Yoo SY, Fan YH, Molkentine DP, Beadle BM, Meyn RE, Myers JN, Heymach JV. Clin Cancer Res. 2017 Jun 1;23(11):2713-2722. doi: 10.1158/1078-0432.CCR-16-2586. Epub 2017 May 5. PMID: 28476872; PMCID: PMC5457365.
February 2017
TRIP12 AS A MEDIATOR OF HUMAN PAPILLOMAVIRUS/P16-RELATED RADIATION ENHANCEMENT EFFECTS.
Wang L, Zhang P, Molkentine DP, Chen C, Molkentine JM, Piao H, Raju U, Zhang J, Valdecanas DR, Tailor RC, Thames HD, Buchholz TA, Chen J, Ma L, Mason KA, Ang KK, Meyn RE, Skinner HD. Oncogene. 2017 Feb 9;36(6):820-828. doi: 10.1038/onc.2016.250. Epub 2016 Jul 18. PMID: 27425591; PMCID: PMC5434711.
September 2016
PROTEOMIC PROFILING IDENTIFIES PTK2/FAK AS A DRIVER OF RADIORESISTANCE IN HPV-NEGATIVE HEAD AND NECK CANCER.
Skinner HD, Giri U, Yang L, Woo SH, Story MD, Pickering CR, Byers LA, Williams MD, El-Naggar A, Wang J, Diao L, Shen L, Fan YH, Molkentine DP, Beadle BM, Meyn RE, Myers JN, Heymach JV. Clin Cancer Res. 2016 Sep 15;22(18):4643-50. doi: 10.1158/1078-0432.CCR-15-2785. Epub 2016 Apr 1. PMID: 27036135; PMCID: PMC5061056.